Reyes Team Molecular mechanisms of membrane proteins

Structural biology and biophysics of membrane transporters and receptors

Reyes Team Molecular mechanisms of membrane proteins

Human solute carriers (hSLC) form a superfamily of integral membrane proteins that transport essential molecules and ions across membranes, and are the cellular receptors of human and pathogenic proteins. Their transport and receptor functions are involved in a wide range of pathological conditions, making hSLCs important emerging drug targets in neurodegeneration, cancer, and infectious diseases, among others.

 

Our research program aims to unravel novel transport, receptor and pharmacological mechanisms of medically important hSLCs using a multidisciplinary biophysical approach. To achieve this, we combined high-resolution cryo-electron microscopy with functional approaches to probe hSLC complexes’ structures, dynamics, and thermodynamics.

Team Leader

  • REYES Nicolas
  • CNRS Research Director
  • %6e%69%63%6f%6c%61%73%2e%72%65%79%65%73%40%75%2d%62%6f%72%64%65%61%75%78%2e%66%72

·      Khare S*, Villalba MI*, Canul-Tec J*, Balsebre Cajiao A*, Kumar A*, Backovic M, Rey F, Pardon E, Steyaert J, Perez C ✉, Reyes N ✉. Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins. Nat. Struct. Mol. Biol. 2024

 

·      Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N ✉. Structural basis of sodium-dependent bile salt uptake into the liver. Nature. 2022 ; 606, p1015-1020.

 

·      Martinez-Molledo M, Nji E, Reyes N ✉. Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2. Nat. Struct. Mol. Biol. 2022; 29, p604-612.

 

·      Kumar A, Planchais C, Fronzes R, Mouquet H,  Reyes N ✉.  Binding Mechanisms of therapeutic antibodies to human CD20. Science. 2020; 369(6505):793-799

 

·      Canul-Tec JC, Assal R, Cirri E, Legrand P, Brier S, Chamot-Rooke J, Reyes N ✉.  Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature. 2017; 544, p446-551

 

·      Reyes N ✉, Oh S, and Boudker O ✉. Binding thermodynamics of a glutamate transporter homolog. Nat. Struct. Mol. Biol. 2013; 20, pp 634-640